Spicy Cajun Chicken Alfredo

Featured in: Quick Weeknight Dinners

This dish combines tender chicken breasts coated in bold Cajun seasoning, cooked to golden perfection, and served over silky fettuccine tossed in a rich Alfredo sauce. The sauce, made with butter, garlic, heavy cream, Parmesan, smoked paprika, and optional chili flakes, creates a creamy base with a smoky heat. Fresh parsley and extra Parmesan add brightness and depth. Ideal for those who appreciate a balanced spicy and creamy comfort meal.

Updated on Sat, 15 Nov 2025 12:58:00 GMT
Tender slices of spicy Cajun Chicken Alfredo atop creamy fettuccine, a comforting dinner. Save
Tender slices of spicy Cajun Chicken Alfredo atop creamy fettuccine, a comforting dinner. | forkina.com

A bold, creamy pasta dish featuring tender Cajun-spiced chicken tossed with fettuccine in a rich Alfredo sauce, perfect for spice lovers.

I first made this for a weekend family dinner when everyone craved something filling with a kick. The tender chicken and velvety sauce won us over instantly.

Ingredients

  • Boneless, skinless chicken breasts: 2 large
  • Cajun seasoning: 2 tablespoons
  • Olive oil: 1 tablespoon
  • Fettuccine: 340 g (12 oz)
  • Unsalted butter: 2 tablespoons
  • Garlic: 3 cloves, minced
  • Heavy cream: 1 cup (240 ml)
  • Parmesan cheese: 1 cup (100 g), freshly grated
  • Smoked paprika: 1/2 teaspoon
  • Chili flakes (optional): 1/2 teaspoon, for extra heat
  • Salt and black pepper: to taste
  • Chopped fresh parsley: 2 tablespoons
  • Extra grated Parmesan cheese: for garnish

Instructions

Cook Pasta:
Cook the fettuccine in salted boiling water until al dente, reserving 1/2 cup pasta water before draining.
Prep Chicken:
Pat chicken breasts dry and coat them evenly with Cajun seasoning.
Sear Chicken:
Heat olive oil in a large skillet over medium-high heat. Add chicken and cook 5 (to) 6 minutes per side until fully cooked and golden brown. Remove and let rest 5 minutes, then slice thinly.
Make Sauce:
In the same skillet, reduce heat to medium and add butter. Sauté minced garlic for 1 minute until fragrant.
Finish Alfredo:
Stir in heavy cream, smoked paprika, and chili flakes. Simmer gently, whisk in Parmesan cheese until melted. Season with salt and pepper.
Toss & Serve:
Add fettuccine to sauce; toss to coat. Add reserved pasta water if needed for silkier sauce. Top with sliced Cajun chicken, chopped parsley, and extra Parmesan. Serve immediately.
This photo features a steaming bowl of flavorful Cajun Chicken Alfredo ready to be enjoyed. Pin it
This photo features a steaming bowl of flavorful Cajun Chicken Alfredo ready to be enjoyed. | forkina.com

We always share this dish on birthdays because the lively Cajun flavors bring excitement to our celebrations and everyone returns for seconds!

Required Tools

Large pot, large skillet, tongs, chefs knife, cutting board, measuring cups and spoons are essential for best results.

Allergen Information

This meal has dairy (cream, butter, Parmesan) and gluten (fettuccine). Cajun seasoning may contain additional allergens so read the packaging carefully.

Nutritional Information

Per serving: 610 calories, 27 g total fat, 54 g carbohydrates, 38 g protein for delicious fuel.

Rich, creamy Alfredo sauce coats the Cajun Chicken Alfredo, a delicious and easy weeknight meal. Pin it
Rich, creamy Alfredo sauce coats the Cajun Chicken Alfredo, a delicious and easy weeknight meal. | forkina.com

Add extra Cajun spice for a bolder kick or more Parmesan for extra richness. This meal sparks joy every time!

Frequently Asked Questions

How do I make the chicken tender and flavorful?

Pat the chicken dry and evenly coat with Cajun seasoning before cooking. Searing on medium-high heat locks in juices and develops a flavorful crust.

Can I adjust the spice level in this dish?

Yes, increase the Cajun seasoning or add more chili flakes to boost the heat according to taste.

What is the best pasta to use for this dish?

Fettuccine works well to hold the creamy sauce, but penne or linguine are excellent alternatives that also absorb flavors nicely.

How do I achieve a smooth Alfredo sauce?

Sautéing garlic in butter before adding cream and cheese ensures flavor. Whisk the sauce gently and add reserved pasta water gradually for a silky texture.

What garnishes complement this dish?

Chopped fresh parsley adds freshness, and extra grated Parmesan enhances the rich, nutty flavor of the sauce.

Spicy Cajun Chicken Alfredo

Creamy Alfredo fettuccine topped with spicy Cajun chicken and fresh parsley garnish.

Prep Time
15 Minutes
Cook Time
25 Minutes
Total Time
40 Minutes


Difficulty: Medium

Cuisine: American

Yield: 4 servings

Dietary: None specified

Ingredients

Chicken

01 2 large boneless, skinless chicken breasts
02 2 tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1 cup heavy cream
04 1 cup freshly grated Parmesan cheese
05 ½ teaspoon smoked paprika
06 ½ teaspoon chili flakes, optional
07 Salt and black pepper, to taste

Garnishes

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan cheese

Instructions

Step 01

Cook Fettuccine: Boil salted water and cook fettuccine until al dente according to package directions. Reserve ½ cup pasta water, then drain and set aside.

Step 02

Prepare Chicken: Pat chicken dry and evenly coat with Cajun seasoning.

Step 03

Sear Chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5–6 minutes per side until golden and cooked through. Remove from skillet, rest 5 minutes, then slice thinly.

Step 04

Sauté Garlic: Reduce heat to medium. Add butter to same skillet and sauté minced garlic for 1 minute until fragrant.

Step 05

Finish Alfredo Sauce: Stir in heavy cream, smoked paprika, and optional chili flakes. Bring to a gentle simmer. Whisk in Parmesan until smooth. Season with salt and pepper.

Step 06

Combine Pasta and Sauce: Toss cooked fettuccine into the sauce, adding reserved pasta water gradually until desired sauce consistency is reached.

Step 07

Serve: Top pasta with sliced Cajun chicken. Garnish with parsley and extra Parmesan. Serve immediately.

Tools You'll Need

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains dairy (butter, heavy cream, Parmesan)
  • Contains gluten (fettuccine)
  • Possible allergens in Cajun seasoning such as mustard or celery

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 610
  • Total Fat: 27 g
  • Total Carbohydrate: 54 g
  • Protein: 38 g